ea0025p334 | Thyroid | SFEBES2011
Zhang Lei
, Grennan-Jones Fiona
, Lane Carol
, Rees D Aled
, Dayan Colin
, Ludgate Marian
Expansion of the orbital contents, by adipogenesis and hyaluronan (HA) overproduction, causes Graves orbitopathy (GO). Orbital HA is generated predominantly by hyaluronan synthase 2 (HAS2) whose transcription is positively regulated by pAkt in cell lines. GO is most frequently associated with Graves disease (GD) in which thyroid stimulating antibodies bind the TSH receptor (TSHR) increasing cAMP. Previous studies highlight a role for TSAB and neutral TSHR ant...